Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.41 |
| ▸ | PDE4A | P27815 | 12/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14174067 | 0.91 | PDE4B (0.41) | PDE4BCYP19A1CYP11B1CYP11B2PDE4D | |
| SCHEMBL5023418 | 0.88 | PDE4B (0.51) | PDE4BCYP19A1CYP11B1CYP11B2PDE4D | |
| SCHEMBL14184645 | 0.85 | CYP19A1 (0.44) | PDE4BCYP19A1CYP11B1CYP11B2MRGPRX1 | |
| SCHEMBL14184005 | 0.83 | PDE4D (0.49) | PDE4BCYP19A1CYP11B1CYP11B2PDE4D | |
| SCHEMBL14184592 | 0.82 | PDE4D (0.58) | PDE4BPDE4DPDE4APDE4CMAPT | |
| SCHEMBL5016409 | 0.80 | MAPT (0.46) | PDE4BPDE4DPDE4APDE4CMAPT | |
| SCHEMBL5026592 | 0.80 | CYP19A1 (0.42) | PDE4BCYP19A1CYP11B1CYP11B2PDE4D | |
| SCHEMBL14174060 | 0.79 | CYP19A1 (0.44) | PDE4BCYP19A1CYP11B1CYP11B2PDE4D | |
| SCHEMBL5017972 | 0.79 | CYP19A1 (0.51) | PDE4BCYP19A1CYP11B1CYP11B2PDE4D | |
| SCHEMBL14174062 | 0.79 | CYP19A1 (0.44) | PDE4BCYP19A1CYP11B1CYP11B2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080146810-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS S.A. (CH) | 2008-06-19 | — | — | US | disclosed |
| US-7238725-B2 | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them | GLENMARK PHARMACEUTICALS LTD. (IN) | 2007-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146810-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LTC4S, TSLP, GPR119 | PDE4B 1684/4885CYP19A1 248/4885CYP11B1 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.