Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 3/20 | 0.60 |
| ▸ | FOXO1 | Q12778 | 7/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.54 |
| ▸ | RIOK2 | Q9BVS4 | 5/20 | 0.50 |
| ▸ | GSK3A | P49840 | 3/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.50 |
| ▸ | SNRK | Q9NRH2 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13373176 | 0.90 | FOXO1 (0.58) | NPY5RFOXO1CCNA2CDK2CCNA1 | |
| SCHEMBL13373143 | 0.88 | FOXO1 (0.57) | NPY5RFOXO1CCNA2CCNE1CDK2 | |
| SCHEMBL13373225 | 0.83 | FOXO1 (0.64) | FOXO1PDE10A | |
| SCHEMBL13373160 | 0.82 | MMP2 (0.54) | NPY5RFOXO1PDE10A | |
| SCHEMBL13373181 | 0.80 | PDE10A (0.55) | NPY5RFOXO1PDE10A | |
| SCHEMBL13373250 | 0.78 | PDE10A (0.47) | FOXO1PDE10A | |
| SCHEMBL6584827 | 0.78 | NPY5R (0.64) | NPY5RCCNB2CCNE2CDK1CCNB1 | |
| SCHEMBL13374845 | 0.78 | FOXO1 (0.52) | FOXO1PDE10A | |
| SCHEMBL13375029 | 0.77 | HPSE (0.62) | FOXO1PDE10A | |
| SCHEMBL6586717 | 0.76 | NPY5R (0.71) | NPY5RCCNB2CCNE2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080125418-A1 | Benzimidazole derivatives and their use as kdr kinase protein inhibitors | AVENTIS PHARMA S.A. (FR) | 2008-05-29 | — | — | US | disclosed |
| US-20080125418-A1 | Benzimidazole derivatives and their use as kdr kinase protein inhibitors | AVENTIS PHARMA S.A. (FR) | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125418-A1 | Benzimidazole derivatives and their use as kdr kinase protein inhibitors | KDR, MUSK, FLT4 | NPY5R 602/4885FOXO1 455/4885CCNB2 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.