Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.59 |
| ▸ | KISS1R | Q969F8 | 4/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | TACR1 | P25103 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14185770 | 1.00 | OPRM1 (0.59) | OPRM1KISS1RPTGS1OPRD1OPRK1 | |
| SCHEMBL14185773 | 0.98 | OPRM1 (0.59) | OPRM1KISS1RPTGS1OPRD1OPRK1 | |
| SCHEMBL14215098 | 0.96 | KISS1R (0.57) | OPRM1KISS1RPTGS1OPRD1OPRK1 | |
| SCHEMBL14185768 | 0.92 | DPP3 (0.49) | OPRM1KISS1R | |
| SCHEMBL14214936 | 0.89 | TACR1 (0.63) | OPRM1KISS1ROPRD1OPRK1TACR1 | |
| SCHEMBL14185776 | 0.86 | OPRM1 (0.49) | OPRM1KISS1RPTGS1OPRD1OPRK1 | |
| Endomorphin-1 SCHEMBL29379764 | 0.83 | — | — | |
| Endomorphin-1 SCHEMBL29577928 | 0.83 | — | — | |
| Endomorphin-1 SCHEMBL21811384 | 0.83 | — | — | |
| Endomorphin-1 SCHEMBL29390342 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378397-B2 | TRH-degrading ectoenzyme inhibitors | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2008-05-27 | — | — | US | disclosed |