Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29980186 | 1.00 | GBA1 (0.38) | GBA1ALDH1A1GBA2L3MBTL1SMN1; SMN2 | |
| SCHEMBL8895914 | 1.00 | GBA1 (0.38) | GBA1ALDH1A1GBA2L3MBTL1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4489522 | 0.98 | GBA1 (0.37) | GBA1ALDH1A1GBA2L3MBTL1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28944195 | 0.98 | GBA1 (0.37) | GBA1ALDH1A1GBA2L3MBTL1SMN1; SMN2 | |
| SCHEMBL20999454 | 0.90 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1SMN1; SMN2RAB9AHTT | |
| SCHEMBL13973961 | 0.84 | GBA1 (0.36) | GBA1ALDH1A1GBA2L3MBTL1SMN1; SMN2 | |
| SCHEMBL19286910 | 0.84 | SMN1; SMN2 (0.44) | GBA1ALDH1A1GBA2SMN1; SMN2GAA | |
| SCHEMBL12155329 | 0.84 | GBA1 (0.51) | GBA1GBA2SMN1; SMN2GAA | |
| SCHEMBL12191642 | 0.84 | GBA1 (0.51) | GBA1GBA2SMN1; SMN2GAA | |
| SCHEMBL8894199 | 0.84 | GBA1 (0.51) | GBA1GBA2SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| EP-2250171-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | Achaogen, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| US-7625909-B2 | Substituted quinazolinone compounds | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2009-12-01 | — | — | US | disclosed |
| WO-2009137130-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| US-7368453-B2 | Quinazolinone compounds with reduced bioaccumulation | CHIRON CORPORATION (US) | 2008-05-06 | — | — | US | disclosed |
| US-20050192297-A1 | Quinazolinone compounds with reduced bioaccumulation | CHIRON CORPORATION GLAXOSMITHKLINE | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | RECQL, BLVRB, NQO2 | GBA1 1298/4885ALDH1A1 1678/4885GBA2 2116/4885 |
| US-20050192297-A1 | Quinazolinone compounds with reduced bioaccumulation | MC4R, MC2R, MC3R | GBA1 837/4885ALDH1A1 1655/4885GBA2 769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.