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Sugi Predict / Compounds / Azidothymidine Monophosphate

Azidothymidine Monophosphate

Azidothymidine Monophosphate

SCHEMBL14188505

Cc1cn([C@H]2C[C@@H](N=[N+]=[N-])[C@@H](COP(=O)(O)O)O2)c(=O)[nH]c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.83
▸ POLA1 P09884 1/20 0.83
▸ POLD1 P28340 1/20 0.83
▸ TK1 P04183 6/20 0.76
▸ LMNA P02545 2/20 0.76
▸ TSHR P16473 2/20 0.76
▸ ALB P02768 1/20 0.76
▸ PKM P14618 1/20 0.76
▸ BLM P54132 1/20 0.76
▸ PMP22 Q01453 1/20 0.76
▸ CYP2D6 P10635 1/20 0.76
▸ ABCG2 Q9UNQ0 3/20 0.73
▸ ABCB1 P08183 1/20 0.73
▸ BCHE P06276 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Azidothymidine Monophosphate SCHEMBL15094301 1.00 POLB (0.83) POLBPOLA1POLD1TK1LMNA
Azidothymidine Monophosphate SCHEMBL13450790 1.00 POLB (0.83) POLBPOLA1POLD1TK1LMNA
SCHEMBL26189175 0.93 POLB (0.79) POLBPOLA1POLD1TK1LMNA
SCHEMBL30272183 0.93 POLB (0.79) POLBPOLA1POLD1TK1LMNA
SCHEMBL21473320 0.93 POLB (0.79) POLBPOLA1POLD1TK1LMNA
SCHEMBL21067527 0.93 POLB (0.96) POLBPOLA1POLD1TK1LMNA
Zidovudine Triphosphate SCHEMBL23585776 0.91 POLB (1.00) POLBPOLA1POLD1TK1LMNA
Zidovudine Triphosphate SCHEMBL19808965 0.91 POLB (1.00) POLBPOLA1POLD1TK1LMNA
SCHEMBL13645135 0.91 POLB (0.75) POLBPOLA1POLD1TK1LMNA
SCHEMBL13987092 0.91 POLB (0.75) POLBPOLA1POLD1TK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170239279-A1 PHOSPHONATE COMPOUNDS UNIV CALIFORNIA (US) 2017-08-24 — — US disclosed
US-9649321-B2 Phosphonate compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-05-16 — — US disclosed
US-20160067268-A1 PHOSPHONATE COMPOUNDS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-03-10 — — US disclosed
US-9206208-B2 Phosphonate compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-12-08 — — US disclosed
US-20150051174-A1 Phosphonate Compounds NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-02-19 — — US disclosed
US-8889658-B2 Phosphonate compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-11-18 — — US disclosed
US-8889658-B2 Phosphonate compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-11-18 — — US disclosed
EP-1914237-B1 Phosphonate ester antiviral compounds UNIV CALIFORNIA (US) 2014-06-18 — — EP disclosed
US-8710030-B2 Phosphonate compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-04-29 — — US disclosed
US-20140045794-A1 Phosphonate Compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-02-13 — — US disclosed
US-20140045794-A1 Phosphonate Compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-02-13 — — US disclosed
US-20130045950-A1 Phosphonate Compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-02-21 — — US disclosed
US-20130045950-A1 Phosphonate Compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-02-21 — — US disclosed
US-7790703-B2 New phosphonate ester derivatives of purine or pyrimidine antivirals; side effect reduction, less toxic, bioavailability THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-09-07 — — US disclosed
US-7687480-B2 Alkylpropanediol derivatized adefovir; reduced toxicity; osteoporosis, bone metabolism disorders , cancer, viral infections THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-03-30 — — US disclosed
US-20080103115-A1 Alkylpropanediol derivatized adefovir; reduced toxicity; osteoporosis, bone metabolism disorders , cancer, viral infections THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2008-05-01 — — US disclosed
US-7279465-B2 Use of amphiphilic nucleoside phosphonoformic acid derivatives for the treatment of viral infectious diseases EBERHARD-KARLS-UNIVERSITAET (DE) 2007-10-09 — — US disclosed
US-20070161602-A1 New phosphonate ester derivatives of purine or pyrimidine antivirals; side effect reduction, less toxic, bioavailability THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2007-07-12 — — US disclosed
US-20070161602-A1 New phosphonate ester derivatives of purine or pyrimidine antivirals; side effect reduction, less toxic, bioavailability THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2007-07-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150051174-A1 Phosphonate Compounds PHPT1, PHOSPHO1, PIK3CA POLB 533/4885POLA1 1115/4885POLD1 1725/4885
US-20140045794-A1 Phosphonate Compounds PHPT1, PHOSPHO1, PIK3CA POLB 533/4885POLA1 1115/4885POLD1 1725/4885
US-20080103115-A1 Alkylpropanediol derivatized adefovir; reduced toxicity; osteoporosis, bone metabolism disorders , cancer, viral infections APRT, AASDHPPT, APOBEC3G POLB 342/4885POLA1 1055/4885POLD1 615/4885
US-20130045950-A1 Phosphonate Compounds PHPT1, PHOSPHO1, PIK3CA POLB 533/4885POLA1 1115/4885POLD1 1725/4885
US-20170239279-A1 PHOSPHONATE COMPOUNDS PHPT1, PHOSPHO1, PIK3CA POLB 533/4885POLA1 1115/4885POLD1 1725/4885
US-20160067268-A1 PHOSPHONATE COMPOUNDS PHPT1, PHOSPHO1, PIK3CA POLB 533/4885POLA1 1115/4885POLD1 1725/4885
US-20070161602-A1 New phosphonate ester derivatives of purine or pyrimidine antivirals; side effect reduction, less toxic, bioavailability PNP, TYMP, UMPS POLB 85/4885POLA1 298/4885POLD1 364/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.