Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | PKLR | P30613 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5020744 | 0.81 | PKM (0.58) | PKMHDAC1HDAC4HDAC8HDAC3 | |
| SCHEMBL14188338 | 0.80 | HDAC1 (0.79) | PKMHDAC1HDAC4HDAC8HDAC3 | |
| SCHEMBL5020703 | 0.80 | HDAC1 (0.74) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL14188725 | 0.78 | HDAC1 (0.77) | HDAC1HDAC4HDAC8KMT2AMEN1 | |
| SCHEMBL12903520 | 0.76 | PKM (0.68) | PKMKMT2AMEN1PKLR | |
| SCHEMBL13762602 | 0.76 | HDAC1 (0.79) | PKMHDAC1HDAC4HDAC8HDAC3 | |
| SCHEMBL14403177 | 0.76 | PKM (0.71) | PKMKMT2AMEN1PKLR | |
| SCHEMBL30532923 | 0.76 | PKM (0.71) | PKMKMT2AMEN1PKLR | |
| SCHEMBL5579317 | 0.75 | KDM4E (0.51) | KMT2AMEN1 | |
| SCHEMBL14629564 | 0.75 | HDAC1 (0.83) | PKMHDAC1HDAC4HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008074132-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2008-06-26 | — | — | WO | disclosed |