Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5020703 | 0.88 | HDAC1 (0.74) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL5020769 | 0.85 | HDAC1 (0.78) | HDAC1HDAC4HDAC8ALDH1A1MAPT | |
| SCHEMBL5020759 | 0.83 | HDAC1 (0.77) | PKMHDAC1HDAC4HDAC8ALDH1A1 | |
| SCHEMBL5020766 | 0.83 | HDAC1 (0.80) | HDAC1HDAC4HDAC8ALDH1A1MAPT | |
| SCHEMBL5020753 | 0.82 | HDAC1 (0.78) | PKMHDAC1HDAC4HDAC8ALDH1A1 | |
| SCHEMBL5020762 | 0.81 | HDAC1 (0.76) | PKMHDAC1HDAC4HDAC8HDAC3 | |
| SCHEMBL5020756 | 0.81 | HDAC1 (0.76) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL14188726 | 0.81 | PKM (0.63) | PKMHDAC1HDAC4HDAC8HDAC3 | |
| SCHEMBL5020774 | 0.79 | HDAC1 (0.77) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL5020761 | 0.79 | HDAC1 (0.79) | HDAC1HDAC4HDAC8ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE43343-E1 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-05-01 | — | — | US | disclosed |