Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 6/20 | 0.52 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | B3GAT3 | O94766 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12658205 | 0.91 | NR4A2 (0.44) | NR4A2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| Lynamicin B SCHEMBL12658014 | 0.90 | NR4A2 (0.55) | NR4A2KDM4EHSD17B10RAB9AALDH1A1 | |
| SCHEMBL12658114 | 0.88 | SPR (0.42) | NR4A2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| Lynamicin A SCHEMBL12658027 | 0.83 | NR4A2 (0.61) | NR4A2KDM4EHSD17B10RAB9AALDH1A1 | |
| SCHEMBL12658130 | 0.82 | NR4A2 (0.51) | NR4A2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL14188731 | 0.82 | SPR (0.41) | NR4A2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL12658267 | 0.81 | MAP2K1 (0.48) | — | |
| SCHEMBL12658220 | 0.79 | SPR (0.43) | NR4A2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL12658273 | 0.79 | NR4A2 (0.61) | NR4A2ALDH1A1MAPTMTNR1AMTNR1B | |
| SCHEMBL14215657 | 0.79 | KDM4E (0.46) | NR4A2KDM4ELMNAALDH1A1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375129-B2 | Bis-indole pyrroles useful as antimicrobials agents | NEREUS PHARMACEUTICALS, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| US-7166634-B2 | Bis-indole pyrroles useful as antimicrobials agents | NEREUS PHARMACEUTICALS, INC. (US) | 2007-01-23 | — | — | US | disclosed |