Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 5/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 12/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 12/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 12/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 10/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 10/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 10/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 10/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lynamicin B SCHEMBL12658014 | 0.92 | NR4A2 (0.55) | NR4A2MEN1MTNR1AMTNR1BKMT2A | |
| SCHEMBL14188735 | 0.91 | NR4A2 (0.52) | NR4A2PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL12658114 | 0.90 | SPR (0.42) | NR4A2PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL12658267 | 0.87 | MAP2K1 (0.48) | — | |
| Lynamicin A SCHEMBL12658027 | 0.84 | NR4A2 (0.61) | NR4A2MEN1MTNR1AMTNR1BKMT2A | |
| SCHEMBL14188731 | 0.83 | SPR (0.41) | NR4A2PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL12658130 | 0.83 | NR4A2 (0.51) | NR4A2PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL12658220 | 0.81 | SPR (0.43) | NR4A2PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL12658273 | 0.79 | NR4A2 (0.61) | NR4A2MEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14215657 | 0.79 | KDM4E (0.46) | NR4A2MEN1LMNAMAPK1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711486-B1 | BIS-INDOLE PYRROLES USEFUL AS ANTIMICROBIAL AGENTS | NEREUS PHARMACEUTICALS INC (US) | 2011-05-11 | — | — | EP | disclosed |
| US-7375129-B2 | Bis-indole pyrroles useful as antimicrobials agents | NEREUS PHARMACEUTICALS, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375129-B2 | Bis-indole pyrroles useful as antimicrobials agents | NEREUS PHARMACEUTICALS, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| US-20070149601-A1 | Bis-indole pyrroles useful as antimicrobials agents | PRIVATE LIFE BIOMED AG (DE) | 2007-06-28 | — | — | US | disclosed |
| US-20070149601-A1 | Bis-indole pyrroles useful as antimicrobials agents | PRIVATE LIFE BIOMED AG (DE) | 2007-06-28 | — | — | US | disclosed |
| US-7166634-B2 | Bis-indole pyrroles useful as antimicrobials agents | NEREUS PHARMACEUTICALS, INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-7166634-B2 | Bis-indole pyrroles useful as antimicrobials agents | NEREUS PHARMACEUTICALS, INC. (US) | 2007-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149601-A1 | Bis-indole pyrroles useful as antimicrobials agents | IDO1, IDO2, TPH1 | NR4A2 4802/4885PRKAG1 3961/4885PRKAA1 944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.