SCHEMBL14190850

SCHEMBL14190850

CC(C)(C)OC(=O)N1CCC(Nc2nccc(N)n2)CC1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.56
ALDH1A1 P00352 2/20 0.54
NPC1 O15118 1/20 0.53
MAPT P10636 1/20 0.53
MAPK1 P28482 1/20 0.53
HTT P42858 1/20 0.53
RAB9A P51151 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
CDK2 P24941 2/20 0.51
CCNA2 P20248 1/20 0.51
IDH1 O75874 1/20 0.48
IDH2 P48735 1/20 0.48
GPR119 Q8TDV5 6/20 0.47
PTPN2 P17706 1/20 0.47
PTPN1 P18031 1/20 0.47
PTPN6 P29350 1/20 0.47
SYK P43405 1/20 0.47
USP30 Q70CQ3 1/20 0.46
BTK Q06187 1/20 0.46
EPHX1 P07099 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14190733 0.87 ALDH1A1 (0.55) ADORA2AALDH1A1NPC1MAPTMAPK1
SCHEMBL12367077 0.87 ALDH1A1 (0.55) ADORA2AALDH1A1NPC1MAPTMAPK1
SCHEMBL3778502 0.84 ALDH1A1 (0.55) ADORA2AALDH1A1NPC1MAPTMAPK1
SCHEMBL3775324 0.84 IDH1 (0.60) ADORA2AALDH1A1NPC1MAPTMAPK1
SCHEMBL4062890 0.84 GPR119 (0.61) ADORA2AALDH1A1NPC1MAPTMAPK1
SCHEMBL27227572 0.84 CTSK (0.55) ADORA2AALDH1A1NPC1MAPTMAPK1
SCHEMBL30874475 0.84 CTSK (0.55) ADORA2AALDH1A1NPC1MAPTMAPK1
SCHEMBL3789071 0.82 ALDH1A1 (0.54) ADORA2AALDH1A1NPC1MAPTMAPK1
SCHEMBL12367054 0.82 ADORA2A (0.52) ADORA2AALDH1A1NPC1MAPTMAPK1
SCHEMBL21876063 0.81 ALDH1A1 (0.60) ADORA2AALDH1A1NPC1MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008071587-A2 2-(PIPERIDIN-4-YL)-4-PHENOXY- OR PHENYLAMINO-PYRIMIDINE DERIVATIVES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2008-06-19 WO disclosed