Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CDC25A | P30304 | 2/20 | 0.49 |
| ▸ | CDC25B | P30305 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PDE6D | O43924 | 3/20 | 0.46 |
| ▸ | MGAM | O43451 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14195569 | 0.79 | CYP3A4 (0.56) | KDM4ECYP3A4TSHRALDH1A1HTT | |
| SCHEMBL28483906 | 0.77 | PDE6D (0.60) | KDM4ETSHRALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL14195584 | 0.77 | TSHR (0.63) | KDM4ECYP3A4TSHRALDH1A1HTT | |
| SCHEMBL7519882 | 0.76 | TSHR (0.53) | KDM4ECYP3A4TSHRALDH1A1HTT | |
| SCHEMBL14195568 | 0.75 | TSHR (0.52) | KDM4ECYP3A4TSHRALDH1A1HTT | |
| SCHEMBL1104386 | 0.75 | ALDH1A1 (0.59) | KDM4ECYP3A4TSHRALDH1A1HTT | |
| SCHEMBL28489677 | 0.73 | PDE6D (0.56) | ALDH1A1HTTSMN1; SMN2TP53MAPT | |
| SCHEMBL3904873 | 0.72 | TSHR (0.67) | KDM4ECYP3A4TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL13832027 | 0.71 | NPSR1 (0.70) | TSHRCDC25ACDC25BALDH1A1HTT | |
| SCHEMBL28478381 | 0.71 | PDE6D (0.70) | PDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361669-B2 | Compositions and method for inhibiting TGF-β | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-04-22 | — | — | US | disclosed |