Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
| ▸ | PDE6D | O43924 | 1/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14195569 | 0.82 | CYP3A4 (0.56) | TSHRCYP3A4KDM4EALDH1A1PDE5A | |
| SCHEMBL7519882 | 0.79 | TSHR (0.53) | TSHRCYP3A4KDM4EALDH1A1PDE5A | |
| SCHEMBL6266316 | 0.78 | ALDH1A1 (0.63) | TSHRCYP3A4ALDH1A1MAPTKMT2A | |
| SCHEMBL14195568 | 0.78 | TSHR (0.52) | TSHRCYP3A4KDM4EALDH1A1PDE5A | |
| SCHEMBL11919912 | 0.77 | TNKS2 (0.58) | TSHRCYP3A4ALDH1A1MAPTKMT2A | |
| SCHEMBL14195583 | 0.77 | KDM4E (0.52) | TSHRCYP3A4KDM4EALDH1A1PDE5A | |
| SCHEMBL13832027 | 0.76 | NPSR1 (0.70) | TSHRALDH1A1MAPTALOX15GAA | |
| SCHEMBL6246323 | 0.76 | SMN1; SMN2 (0.65) | TSHRCYP3A4KDM4EALDH1A1KMT2A | |
| SCHEMBL3904873 | 0.75 | TSHR (0.67) | TSHRCYP3A4KDM4EALDH1A1KMT2A | |
| SCHEMBL7512001 | 0.72 | QPCTL (0.58) | TSHRCYP3A4KDM4EALDH1A1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361669-B2 | Compositions and method for inhibiting TGF-β | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-04-22 | — | — | US | disclosed |