Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14195569 | 0.80 | CYP3A4 (0.56) | TSHRCYP3A4PDE5AKDM4EALDH1A1 | |
| SCHEMBL11920072 | 0.79 | OXTR (0.51) | CYP3A4ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL14195584 | 0.78 | TSHR (0.63) | TSHRCYP3A4PDE5AKDM4EALDH1A1 | |
| SCHEMBL7519882 | 0.77 | TSHR (0.53) | TSHRCYP3A4PDE5AKDM4EALDH1A1 | |
| SCHEMBL13446882 | 0.76 | CYP1A2 (0.54) | TSHRKDM4EALDH1A1MAPTGAA | |
| SCHEMBL14195583 | 0.75 | KDM4E (0.52) | TSHRCYP3A4PDE5AKDM4EALDH1A1 | |
| SCHEMBL1544452 | 0.72 | ALDH1A1 (0.43) | TSHRCYP3A4KDM4EALDH1A1MAPT | |
| SCHEMBL7512001 | 0.70 | QPCTL (0.58) | TSHRCYP3A4PDE5AKDM4EALDH1A1 | |
| SCHEMBL10288359 | 0.70 | PDE5A (0.59) | TSHRCYP3A4PDE5AKDM4EALDH1A1 | |
| SCHEMBL23063346 | 0.68 | KDM4E (0.48) | KDM4EALDH1A1MAPTALOX15GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361669-B2 | Compositions and method for inhibiting TGF-β | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-04-22 | — | — | US | disclosed |