Sugi Predict

Sugi Predict / Compounds / SCHEMBL14197992

SCHEMBL14197992

SCHEMBL14197992

c1ccc([C@@H]2COCN2)cc1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.43
▸ PRCP P42785 1/20 0.42
▸ MEN1 O00255 4/20 0.38
▸ KMT2A Q03164 4/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ SLC6A2 P23975 1/20 0.36
▸ ADRA1A P35348 1/20 0.36
▸ HTR2B P41595 1/20 0.36
▸ SLC6A3 Q01959 1/20 0.36
▸ SLC18A3 Q16572 1/20 0.34
▸ SIGMAR1 Q99720 1/20 0.34
▸ GBA1 P04062 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ CYP2C19 P33261 1/20 0.33
▸ TAAR1 Q96RJ0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4307186 1.00 TSHR (0.43) TSHRPRCPMEN1KMT2ANPC1
SCHEMBL13301525 1.00 TSHR (0.43) TSHRPRCPMEN1KMT2ANPC1
SCHEMBL1333525 0.79 PRKACA (0.49) TSHRPRCPMEN1KMT2ASLC6A2
SCHEMBL22097636 0.79 KDM1A (0.36) TSHRPRCPSLC6A2HTR2BSLC6A3
SCHEMBL30370485 0.79 KDM1A (0.36) TSHRPRCPSLC6A2HTR2BSLC6A3
SCHEMBL1333528 0.79 PRKACA (0.49) TSHRPRCPMEN1KMT2ASLC6A2
SCHEMBL1335278 0.79 PRKACA (0.49) TSHRPRCPMEN1KMT2ASLC6A2
SCHEMBL14197971 0.79 PRCP (0.40) TSHRPRCPMEN1KMT2ANPC1
SCHEMBL30370147 0.79 MAPT (0.47) PRCPMEN1KMT2AHTR2BKDM4E
Hydrochloric Acid SCHEMBL1849039 0.78 PRKACA (0.48) TSHRPRCPMEN1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115710180-A Method for asymmetrically synthesizing sex pheromone of mealybugs of hibiscus syriacus 中国农业大学 2023-02-24 — — CN claimed
CN-115710180-B Method for asymmetrically synthesizing mealy bugle sex pheromone of hibiscus mani 中国农业大学 2025-06-27 — — CN disclosed
WO-2024008166-A1 α,β-UNSATURATED AMIDE COMPOUND, AND PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 中国科学院上海药物研究所 2024-01-11 — — WO disclosed
CN-115710180-A Method for asymmetrically synthesizing sex pheromone of mealybugs of hibiscus syriacus 中国农业大学 2023-02-24 — — CN disclosed
CN-115710180-A Method for asymmetrically synthesizing sex pheromone of mealybugs of hibiscus syriacus 中国农业大学 2023-02-24 — — CN disclosed
US-11478438-B2 Necrosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2022-10-25 — — US disclosed
CN-107108492-B Cell necrosis inhibitor 北京生命科学研究所 2021-03-19 — — CN disclosed
US-20200182617-A1 Necrosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2020-06-11 — — US disclosed
US-10555920-B2 Necrosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2020-02-11 — — US disclosed
US-20190038578-A1 Necrosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2019-02-07 — — US disclosed
US-10092529-B2 Necrosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2018-10-09 — — US disclosed
EP-3224245-B1 NECROSIS INHIBITORS NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) 2018-09-12 — — EP disclosed
US-20170304237-A1 Necrosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2017-10-26 — — US disclosed
EP-3224245-A1 NECROSIS INHIBITORS National Institute Of Biological Sciences, Beijing (CN) 2017-10-04 — — EP disclosed
WO-2016101887-A1 NECROSIS INHIBITORS NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2016-06-30 — — WO disclosed
US-7354946-B2 prominent growth inhibitory activity against tumor cells; cyclin dependent kinase inhibitors; colon cancer; N'-(3-t-butylisoindolino[3,2-b]oxazolidin-4-on-8-yl)-N-(4-(N-benzylpyrrolidin-3-yl)pyridin-2-yl)urea BANYU PHARMACEUTICAL CO., LTD. (JP) 2008-04-08 — — US disclosed
US-20070027147-A1 Biarylurea derivatives MSD K.K. (JP) 2007-02-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170304237-A1 Necrosis Inhibitors RIPK3, RIPK1, RIPK4 TSHR 1927/4885PRCP 4691/4885MEN1 3275/4885
US-11478438-B2 Necrosis inhibitors RIPK3, RIPK1, RIPK4 TSHR 2122/4885PRCP 4720/4885MEN1 3176/4885
US-20070027147-A1 Biarylurea derivatives CDK6, CDK4, CCNI TSHR 1293/4885PRCP 4090/4885MEN1 3166/4885
US-20190038578-A1 Necrosis Inhibitors RIPK3, RIPK1, RIPK4 TSHR 2122/4885PRCP 4720/4885MEN1 3176/4885
US-10092529-B2 Necrosis inhibitors RIPK3, RIPK1, RIPK4 TSHR 1927/4885PRCP 4691/4885MEN1 3275/4885
US-10555920-B2 Necrosis inhibitors RIPK3, RIPK1, RIPK4 TSHR 2122/4885PRCP 4720/4885MEN1 3176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.