Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.60 |
| ▸ | NQO2 | P16083 | 1/20 | 0.60 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.60 |
| ▸ | PDE1A | P54750 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.47 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12049397 | 0.90 | MET (0.68) | METPDE3BPDE3ANQO2PIP4K2C | |
| SCHEMBL10242471 | 0.87 | MET (0.71) | METPDE3BPDE3ANQO2PIP4K2C | |
| SCHEMBL12049398 | 0.86 | MET (0.64) | METPDE3BPDE3ANQO2PIP4K2C | |
| SCHEMBL10242512 | 0.86 | MET (0.73) | METPDE3BPDE3ANQO2PIP4K2C | |
| SCHEMBL10242499 | 0.85 | MET (0.66) | METPDE3BPDE3ANQO2PIP4K2C | |
| SCHEMBL10242511 | 0.84 | MET (0.65) | METPDE3BPDE3ANQO2PIP4K2C | |
| SCHEMBL14199540 | 0.83 | MET (0.44) | METPDE3BPDE3ANQO2PIP4K2C | |
| SCHEMBL12049503 | 0.81 | MET (0.81) | METPDE3BPDE3ANQO2PIP4K2C | |
| SCHEMBL12049487 | 0.81 | MET (0.81) | METPDE3BPDE3ANQO2PIP4K2C | |
| SCHEMBL14199040 | 0.81 | MET (0.58) | METPDE3BPDE3ANQO2PIP4K2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008051805-A2 | TRIAZOLO-PYRIDAZINE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-05-02 | — | — | WO | disclosed |