Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | CD74 | P04233 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CBX7 | O95931 | 1/20 | 0.39 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.39 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14518249 | 0.81 | MIF (0.65) | MIFHPGDMAPK1USP2TSHR | |
| SCHEMBL2757855 | 0.79 | MIF (0.70) | MIFMAPK1TSHRNPC1ALDH1A1 | |
| SCHEMBL14198763 | 0.78 | MAPK1 (0.70) | MIFHPGDMAPK1USP2TSHR | |
| SCHEMBL3063571 | 0.78 | LMNA (0.49) | MIFHPGDKMT2AALDH1A1APEX1 | |
| SCHEMBL14199043 | 0.78 | POLB (0.52) | MIFHPGDKMT2AALDH1A1NPSR1 | |
| SCHEMBL14198915 | 0.76 | KMO (0.49) | ALDH1A1NPSR1 | |
| SCHEMBL14198929 | 0.76 | NPC1 (0.39) | MIFHPGDMAPK1USP2TSHR | |
| SCHEMBL11218178 | 0.74 | MIF (0.54) | MIFHPGDMAPK1USP2TSHR | |
| SCHEMBL14198758 | 0.72 | IDO1 (0.66) | — | |
| SCHEMBL14198764 | 0.72 | MIF (0.65) | MIFHPGDUSP2TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608627-B1 | BICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2008-05-07 | — | — | EP | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |