Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CDYL2 | Q8N8U2 | 5/20 | 0.48 |
| ▸ | CDYL | Q9Y232 | 5/20 | 0.48 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 3/20 | 0.47 |
| ▸ | CD74 | P04233 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.46 |
| ▸ | CBX7 | O95931 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717564 | 0.86 | MET (0.55) | POLBMETMAPTKMOALDH1A1 | |
| SCHEMBL14518249 | 0.81 | MIF (0.65) | POLBALDH1A1HPGDKMT2AMIF | |
| SCHEMBL8798927 | 0.80 | MET (0.57) | POLBMETMAPTKMOALDH1A1 | |
| Hydrochloric Acid SCHEMBL9157992 | 0.79 | MET (0.56) | POLBMETMAPTKMOALDH1A1 | |
| SCHEMBL4242148 | 0.79 | KMO (0.61) | POLBMETKMOCDYL2CDYL | |
| SCHEMBL13140318 | 0.78 | TP53 (0.58) | POLBMETMAPTKMOALDH1A1 | |
| SCHEMBL2149713 | 0.78 | MAPT (0.56) | POLBMETMAPTKMOALDH1A1 | |
| SCHEMBL4413088 | 0.78 | HPGD (0.59) | POLBMETKMOHPGDCDYL2 | |
| SCHEMBL14199075 | 0.78 | MIF (0.48) | ALDH1A1HPGDNPSR1CDYLCDY1; CDY1B | |
| SCHEMBL4228726 | 0.77 | MAPT (0.58) | POLBMETMAPTKMOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608627-B1 | BICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2008-05-07 | — | — | EP | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |