Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200286 | 0.89 | TSHR (0.33) | TSHRSMN1; SMN2GAAMAPK1NR1H3 | |
| SCHEMBL14200301 | 0.84 | CHRNB2 (0.37) | GAAMAPK1ALDH1A1KMT2A | |
| SCHEMBL14200244 | 0.82 | ALDH1A1 (0.34) | TSHRSMN1; SMN2GAAALDH1A1MEN1 | |
| SCHEMBL6893715 | 0.82 | TSHR (0.43) | TSHRSMN1; SMN2GAAMAPK1NR1H3 | |
| SCHEMBL13301217 | 0.81 | TSHR (0.37) | TSHRSMN1; SMN2GAAMAPK1NR1H3 | |
| SCHEMBL12207794 | 0.81 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL12447048 | 0.79 | CHRM2 (0.33) | TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL11300741 | 0.79 | CA12 (0.47) | TSHRSMN1; SMN2GAAMAPK1NR1H3 | |
| SCHEMBL18932498 | 0.79 | TSHR (0.36) | TSHRSMN1; SMN2GAAMAPK1NR1H3 | |
| SCHEMBL10087787 | 0.77 | MGLL (0.42) | TSHRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |