Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 10/20 | 0.31 |
| ▸ | CA1 | P00915 | 8/20 | 0.31 |
| ▸ | CA9 | Q16790 | 7/20 | 0.31 |
| ▸ | CA12 | O43570 | 3/20 | 0.31 |
| ▸ | CA7 | P43166 | 3/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.31 |
| ▸ | CA3 | P07451 | 2/20 | 0.31 |
| ▸ | CA4 | P22748 | 2/20 | 0.31 |
| ▸ | CA6 | P23280 | 2/20 | 0.31 |
| ▸ | CA5A | P35218 | 2/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 2/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200417 | 0.98 | BMP1 (0.32) | CNR2FAAHBMP1 | |
| SCHEMBL14200415 | 0.94 | BMP1 (0.35) | CNR2BMP1 | |
| SCHEMBL14229340 | 0.86 | CNR2 (0.40) | CNR2FAAHBMP1CA2CA1 | |
| SCHEMBL14200363 | 0.86 | FAAH (0.38) | CNR2FAAHCA2CA1CA12 | |
| SCHEMBL14201273 | 0.86 | FAAH (0.38) | CNR2FAAHCA2CA1CA12 | |
| SCHEMBL14200355 | 0.86 | CNR2 (0.40) | CNR2FAAHBMP1CA2 | |
| SCHEMBL14200201 | 0.85 | BMP1 (0.35) | CNR2BMP1 | |
| SCHEMBL14229525 | 0.84 | CNR2 (0.38) | CNR2FAAHBMP1CA2CA1 | |
| SCHEMBL14200354 | 0.84 | CNR2 (0.38) | CNR2FAAHBMP1CA2 | |
| SCHEMBL14200353 | 0.84 | CA1 (0.39) | CNR2FAAHBMP1CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |