Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1922261 | 1.00 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| SCHEMBL7712450 | 1.00 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| SCHEMBL7687272 | 1.00 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| SCHEMBL7706563 | 1.00 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| Hydrochloric Acid SCHEMBL1894628 | 0.99 | KDM4E (0.60) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| Hydrochloric Acid SCHEMBL1784781 | 0.99 | KDM4E (0.60) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| SCHEMBL14541670 | 0.89 | OPRM1 (0.54) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| SCHEMBL3850930 | 0.85 | KDM4E (0.75) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| Hydrochloric Acid SCHEMBL1893884 | 0.85 | KDM4E (0.54) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| SCHEMBL1921582 | 0.83 | KDM4E (0.53) | KDM4EALOX15HSD17B10KMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124866-A1 | PROCESS FOR PREPARATION OF TADALAFIL | Zaklady Famaceutyczne Polpharma SA (PL) | 2011-05-26 | — | — | US | claimed |
| US-20110124866-A1 | PROCESS FOR PREPARATION OF TADALAFIL | Zaklady Famaceutyczne Polpharma SA (PL) | 2011-05-26 | — | — | US | disclosed |
| US-20110124866-A1 | PROCESS FOR PREPARATION OF TADALAFIL | Zaklady Famaceutyczne Polpharma SA (PL) | 2011-05-26 | — | — | US | disclosed |
| EP-2297149-A1 | PROCESS FOR PREPARATION OF TADALAFIL | Zaklady Farmaceutyczne "Polpharma" S.A. (PL) | 2011-03-23 | — | — | EP | disclosed |
| EP-2297149-A1 | PROCESS FOR PREPARATION OF TADALAFIL | Zaklady Farmaceutyczne "Polpharma" S.A. (PL) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009047613-A3 | AN IMPROVED PROCESS FOR THE PREPARATION OF TADALAFIL INTERMEDIATE | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009047613-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF TADALAFIL INTERMEDIATE | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2009-04-16 | — | — | WO | disclosed |
| US-7223863-B2 | Process for preparing Tadalafil and its intermediate | ALEMBIC LIMITED (IN) | 2007-05-29 | — | — | US | disclosed |
| US-20060258865-A1 | Process for preparing Tadalafil and its intermediate | ALEMBIC LIMITED (IN) | 2006-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258865-A1 | Process for preparing Tadalafil and its intermediate | PDE3B, PDE5A, PDE3A | KDM4E 1771/4885ALOX15 3071/4885HSD17B10 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.