Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1922009 | 0.86 | KDM4E (0.52) | KDM4EALOX15HSD17B10KMT2AMEN1 | |
| SCHEMBL7712450 | 0.83 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AMEN1 | |
| SCHEMBL7687272 | 0.83 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AMEN1 | |
| SCHEMBL7706563 | 0.83 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AMEN1 | |
| SCHEMBL1922261 | 0.83 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AMEN1 | |
| SCHEMBL1420044 | 0.83 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL1894628 | 0.82 | KDM4E (0.60) | KDM4EALOX15HSD17B10KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL1784781 | 0.82 | KDM4E (0.60) | KDM4EALOX15HSD17B10KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL1893884 | 0.80 | KDM4E (0.54) | KDM4EALOX15HSD17B10KMT2AMEN1 | |
| SCHEMBL14541670 | 0.73 | OPRM1 (0.54) | KDM4EALOX15HSD17B10KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2327408-A1 | Tetracyclic cyclic gmp-specific phosphodiesterase inhibitors for the treatment of benign prostatic hypertrophy | ICOS Corporation (US) | 2011-06-01 | — | — | EP | disclosed |