Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1922261 | 1.00 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| SCHEMBL7687272 | 1.00 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| SCHEMBL7706563 | 1.00 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| SCHEMBL1420044 | 1.00 | KDM4E (0.61) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| Hydrochloric Acid SCHEMBL1894628 | 0.99 | KDM4E (0.60) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| Hydrochloric Acid SCHEMBL1784781 | 0.99 | KDM4E (0.60) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| SCHEMBL14541670 | 0.89 | OPRM1 (0.54) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| SCHEMBL3850930 | 0.85 | KDM4E (0.75) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| Hydrochloric Acid SCHEMBL1893884 | 0.85 | KDM4E (0.54) | KDM4EALOX15HSD17B10KMT2AOPRM1 | |
| SCHEMBL1921582 | 0.83 | KDM4E (0.53) | KDM4EALOX15HSD17B10KMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369059-B1 | INHIBITOR OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE (CGMP SPECIFIC PDE); CARDIOVASCULAR DISORDERS; PYRAZINO(2',1':6,1)PYRIDO(3,4-B)INDOLE-1,4-DIONES | ICOS CORPORATION | 2002-04-09 | — | — | US | disclosed |
| US-6127542-A | CHEMICAL INTERMEDIATES TO SPECIFIED PYRAZINO(2',1':6,1)PYRIDO(3,4B)INDOLE-1,4-DIONES WHICH ARE SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE; TO TREAT CARDIOVASCULAR DISORDERS | ICOS CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |