Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 10/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13633643 | 0.77 | P2RY12 (0.42) | P2RY12FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL9922651 | 0.77 | P2RY12 (0.42) | P2RY12FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL24968466 | 0.74 | CYP19A1 (0.57) | CYP19A1 | |
| SCHEMBL9922561 | 0.74 | P2RY12 (0.44) | P2RY12FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL1548736 | 0.74 | P2RY12 (0.49) | P2RY12FBP1MEN1KMT2AMAPT | |
| SCHEMBL13633800 | 0.73 | KDR (0.38) | P2RY12FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL9922556 | 0.72 | P2RY12 (0.43) | P2RY12FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL12706443 | 0.72 | P2RY12 (0.51) | P2RY12FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL9922652 | 0.71 | P2RY12 (0.44) | P2RY12FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL9923094 | 0.71 | CASP6 (0.46) | P2RY12FBP1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358257-B2 | sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives; effective for prevention and treatment of cardiovascular diseases, antithrombotic agents | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-04-15 | — | — | US | disclosed |
| US-7358257-B2 | sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives; effective for prevention and treatment of cardiovascular diseases, antithrombotic agents | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-04-15 | — | — | US | disclosed |