Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229539 | 0.91 | PKM (0.41) | PKMPOLBCYP2C19MAPTNPC1 | |
| SCHEMBL14200795 | 0.89 | PKM (0.44) | PKMPOLBCYP2C19MAPTNPC1 | |
| SCHEMBL14230034 | 0.87 | MAPT (0.47) | PKMPOLBMAPTNPC1MEN1 | |
| SCHEMBL14200759 | 0.79 | PKM (0.47) | PKMPOLBCYP2C19MAPTNPC1 | |
| SCHEMBL14200794 | 0.77 | PKM (0.45) | PKMPOLBCYP2C19MAPTNPC1 | |
| SCHEMBL14229723 | 0.76 | PKM (0.46) | PKMPOLBCYP2C19MAPTNPC1 | |
| SCHEMBL14200749 | 0.74 | ALDH1A1 (0.38) | PKMPOLBMAPTMEN1KMT2A | |
| SCHEMBL3891691 | 0.71 | PKM (0.55) | PKMPOLBCYP2C19MAPTNPC1 | |
| SCHEMBL16706322 | 0.70 | PKM (0.68) | PKMPOLBCYP2C19MAPTNPC1 | |
| SCHEMBL2790502 | 0.70 | PKM (0.64) | PKMPOLBCYP2C19MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |