Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200752 | 0.90 | AGTR1 (0.38) | ALDH1A1MAPTL3MBTL1MAPK1AGTR1 | |
| SCHEMBL14229890 | 0.87 | ALDH1A1 (0.40) | ALDH1A1MAPTL3MBTL1MAPK1AGTR1 | |
| SCHEMBL14200874 | 0.80 | AGTR1 (0.48) | ALDH1A1MAPTL3MBTL1MAPK1AGTR1 | |
| SCHEMBL14200703 | 0.78 | AGTR1 (0.43) | ALDH1A1MAPTL3MBTL1MAPK1AGTR1 | |
| SCHEMBL14200751 | 0.77 | HPGD (0.37) | ALDH1A1L3MBTL1AGTR1AGTR2SMN1; SMN2 | |
| SCHEMBL14229203 | 0.76 | AGTR1 (0.39) | ALDH1A1MAPTL3MBTL1MAPK1AGTR1 | |
| SCHEMBL14200879 | 0.74 | PKM (0.43) | ALDH1A1MAPTPKMKMT2AMEN1 | |
| SCHEMBL14229389 | 0.70 | AGTR1 (0.47) | ALDH1A1MAPTL3MBTL1MAPK1AGTR1 | |
| SCHEMBL14230028 | 0.68 | AGTR1 (0.51) | ALDH1A1MAPTL3MBTL1MAPK1AGTR1 | |
| SCHEMBL3927132 | 0.67 | PDE10A (0.51) | ALDH1A1MAPTL3MBTL1MAPK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |