Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.37 |
| ▸ | CA1 | P00915 | 6/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | Q9HBH1 | 1/20 | 0.31 | |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14201134 | 0.97 | CA2 (0.35) | CA2CA1MAPK1CA12CA9 | |
| SCHEMBL14201059 | 0.93 | CA2 (0.39) | CA2CA1MAPK1GPR84FFAR1 | |
| SCHEMBL14201044 | 0.93 | CA1 (0.33) | CA2CA1MAPK1CA12CA9 | |
| SCHEMBL14201099 | 0.90 | CA2 (0.35) | CA2CA1MAPK1SLC1A3SLC1A2 | |
| SCHEMBL14201043 | 0.88 | CA1 (0.37) | CA2CA1MAPK1CA12CA9 | |
| SCHEMBL14200905 | 0.87 | GPR84 (0.37) | CA2GPR84FFAR1 | |
| SCHEMBL14201428 | 0.87 | CA2 (0.35) | CA2CA1MAPK1CA12CA9 | |
| SCHEMBL14201092 | 0.82 | HDAC7 (0.31) | — | |
| SCHEMBL14201072 | 0.82 | CA2 (0.34) | CA2CA1MAPK1GPR84FFAR1 | |
| SCHEMBL14201108 | 0.82 | CA2 (0.40) | CA2CA1MAPK1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |