Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200905 | 0.94 | GPR84 (0.37) | CA2GPR84FFAR1EPHX2FFAR4 | |
| SCHEMBL14201045 | 0.93 | CA2 (0.37) | CA2GPR84FFAR1CA1MAPK1 | |
| SCHEMBL14201134 | 0.90 | CA2 (0.35) | CA2GPR84FFAR1CA1MAPK1 | |
| SCHEMBL14201061 | 0.89 | EPHX2 (0.38) | CA2GPR84FFAR1EPHX2CA1 | |
| SCHEMBL14201099 | 0.87 | CA2 (0.35) | CA2GPR84FFAR1CA1MAPK1 | |
| SCHEMBL14201044 | 0.87 | CA1 (0.33) | CA2GPR84FFAR1EPHX2CA1 | |
| SCHEMBL14201072 | 0.86 | CA2 (0.34) | CA2GPR84FFAR1EPHX2CA1 | |
| SCHEMBL14201057 | 0.83 | EPHX2 (0.39) | CA2GPR84FFAR1EPHX2CA1 | |
| SCHEMBL14200985 | 0.83 | GPR84 (0.40) | CA2GPR84FFAR1EPHX2CA1 | |
| SCHEMBL14201131 | 0.82 | EPHX2 (0.40) | GPR84FFAR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |