Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14201151 | 0.92 | POLB (0.32) | — | |
| SCHEMBL14201185 | 0.90 | RIPK1 (0.33) | RIPK1S1PR1CYP1A2CYP2C19GFER | |
| SCHEMBL14201181 | 0.90 | RIPK1 (0.33) | RIPK1CYP1A2CYP2C19GFERSMN1; SMN2 | |
| SCHEMBL14201193 | 0.88 | RIPK1 (0.36) | RIPK1GAA | |
| SCHEMBL14229003 | 0.88 | RIPK1 (0.41) | RIPK1S1PR1 | |
| SCHEMBL14201195 | 0.85 | POLB (0.33) | RIPK1 | |
| SCHEMBL14201153 | 0.85 | RIPK1 (0.34) | RIPK1CYP1A2CYP2C19GFERSMN1; SMN2 | |
| SCHEMBL14201160 | 0.83 | S1PR1 (0.33) | S1PR1CYP1A2CYP2C19GFERSMN1; SMN2 | |
| SCHEMBL14200779 | 0.83 | PSEN1 (0.32) | RIPK1 | |
| SCHEMBL14229510 | 0.81 | MEN1 (0.34) | S1PR1CYP1A2CYP2C19GFERSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |