Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | MLYCD | O95822 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14201161 | 0.92 | RIPK1 (0.32) | — | |
| SCHEMBL14229081 | 0.89 | RIPK1 (0.39) | — | |
| SCHEMBL14201157 | 0.89 | RIPK1 (0.34) | POLBMLYCD | |
| SCHEMBL14201195 | 0.87 | POLB (0.33) | POLBPPARGPPARDPPARA | |
| SCHEMBL14201181 | 0.87 | RIPK1 (0.33) | — | |
| SCHEMBL14201185 | 0.84 | RIPK1 (0.33) | — | |
| SCHEMBL14200885 | 0.84 | — | — | |
| SCHEMBL14201121 | 0.84 | MLYCD (0.32) | POLBPPARGPPARDPPARAMLYCD | |
| SCHEMBL14229889 | 0.82 | MEN1 (0.33) | — | |
| SCHEMBL14543615 | 0.82 | RIPK1 (0.31) | POLBPPARGPPARDPPARAMLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |