Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953559 | 0.85 | ALDH1A1 (0.56) | MAOBALDH1A1KDM4EMAPT | |
| SCHEMBL27722273 | 0.73 | HTR6 (0.41) | MAOBALDH1A1KDM4EHTR6SMN1; SMN2 | |
| SCHEMBL3956732 | 0.73 | MAOB (0.56) | MAOBALDH1A1KDM4EHTR6MAPT | |
| SCHEMBL2898016 | 0.72 | HTR6 (0.40) | ALDH1A1HTR6SMN1; SMN2POLBMAPT | |
| SCHEMBL9149858 | 0.69 | HTR6 (0.40) | ALDH1A1HTR6SMN1; SMN2POLBMAPT | |
| SCHEMBL30065891 | 0.68 | ALDH1A1 (0.61) | MAOBALDH1A1KDM4EMAPT | |
| SCHEMBL9293231 | 0.68 | MAOB (0.46) | MAOBALDH1A1KDM4EHTR6MAPT | |
| SCHEMBL27959927 | 0.67 | HTR6 (0.50) | ALDH1A1HTR6SMN1; SMN2POLBMAPT | |
| SCHEMBL13513169 | 0.65 | HTR2C (0.50) | ALDH1A1HTR6SMN1; SMN2POLBMAPT | |
| SCHEMBL5728450 | 0.65 | MAOB (0.39) | MAOBALDH1A1KDM4EHTR6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831191-B1 | CHROMAN DERIVATIVES AND THEIR USE AS 5-HT RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2008-05-21 | — | — | EP | disclosed |