Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9293411 | 0.89 | MAOB (0.47) | MAOBKDM4EALDH1A1MAPTGLA | |
| SCHEMBL4243740 | 0.79 | KDM4E (0.61) | MAOBKDM4EALDH1A1MAPTGLA | |
| SCHEMBL2953559 | 0.79 | ALDH1A1 (0.56) | MAOBKDM4EALDH1A1MAPTPDE4B | |
| SCHEMBL9869769 | 0.79 | HTR6 (0.46) | HTR6MAPTTP53RXFP1PKM | |
| SCHEMBL9294550 | 0.78 | HTR6 (0.45) | HTR6KDM4EALDH1A1MAPTGLA | |
| SCHEMBL9293420 | 0.76 | TLR3 (0.44) | HTR6KDM4EALDH1A1MAPTGLA | |
| SCHEMBL6279249 | 0.75 | KDM4E (0.50) | MAOBKDM4EALDH1A1MAPTGLA | |
| SCHEMBL10401817 | 0.74 | KDM4E (0.56) | MAOBKDM4EALDH1A1MAPTGLA | |
| SCHEMBL9521842 | 0.73 | HTR6 (0.42) | HTR6KDM4EALDH1A1MAPTGLA | |
| SCHEMBL9294310 | 0.72 | HIF1A (0.48) | HTR6HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5364878-A | Antiasthmatics; urogenital disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-15 | — | — | US | disclosed |
| EP-0351720-B1 | Use of substituted 3,4-dihydro-2H-benzopyrans as medicaments against obstructive disorders of the lung | HOECHST AG (DE) | 1994-08-24 | — | — | EP | disclosed |
| EP-0560399-A1 | Use of substituted 3,4-dihydro-2H-benzopyrans as medicament against disorders of the urethra | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-15 | — | — | EP | disclosed |
| EP-0277612-B1 | SUBSTITUTED 3,4-DIHYDRO-2H-BENZOPYRANES, PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-28 | — | — | EP | disclosed |
| EP-0277611-B1 | ALKYL-SUBSTITUTED N-BENZOPYRANYL LACTAMES, PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS ON THE BASIS OF THESE COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-16 | — | — | EP | disclosed |
| US-5043344-A | Unsaturated N-benzopyranyllactams | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-27 | — | — | US | disclosed |
| US-4999371-A | Treating Cardiovascular Disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-12 | — | — | US | disclosed |
| EP-0351720-A2 | Use of substituted 3,4-dihydro-2H-benzopyrans as medicaments against obstructive disorders of the lung | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-01-24 | — | — | EP | disclosed |
| EP-0337179-A1 | Unsaturated N-benzopyranyllactams | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-10-18 | — | — | EP | disclosed |
| EP-0277611-A2 | Alkyl-substituted N-benzopyranyl lactames, process for their preparation, their use and pharmaceutical preparations on the basis of these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-10 | — | — | EP | disclosed |
| EP-0277612-A2 | Substituted 3,4-dihydro-2H-benzopyranes, process for their preparation, their use and pharmaceutical preparations based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-10 | — | — | EP | disclosed |