Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200772 | 0.86 | HTT (0.34) | L3MBTL1TSPOMEN1KMT2AHPGD | |
| SCHEMBL14200771 | 0.84 | HTT (0.35) | L3MBTL1TSPOMEN1KMT2AHPGD | |
| SCHEMBL14200769 | 0.83 | TSPO (0.32) | TP53SMN1; SMN2L3MBTL1TSPOMEN1 | |
| SCHEMBL14200832 | 0.81 | TAS1R3 (0.32) | TP53L3MBTL1TSPOMEN1KMT2A | |
| SCHEMBL14200798 | 0.80 | NPC1 (0.34) | ALDH1A1TP53 | |
| SCHEMBL11416334 | 0.79 | ALDH1A1 (0.62) | ALDH1A1LMNATP53SMN1; SMN2TSPO | |
| SCHEMBL14200762 | 0.79 | NPC1 (0.33) | ALDH1A1TP53L3MBTL1HPGD | |
| SCHEMBL14229509 | 0.78 | TP53 (0.40) | ALDH1A1LMNATP53SMN1; SMN2TSPO | |
| SCHEMBL15085775 | 0.78 | ALDH1A1 (0.65) | ALDH1A1LMNATP53SMN1; SMN2MEN1 | |
| SCHEMBL14200778 | 0.72 | TP53 (0.39) | ALDH1A1TP53L3MBTL1TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |