Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.47 |
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | PPARA | Q07869 | 4/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1696256 | 0.82 | DAO (0.54) | BACE1DAOMRGPRX4PPARGPPARA | |
| SCHEMBL27740487 | 0.82 | BACE1 (0.51) | BACE1DAOMRGPRX4PPARGPPARA | |
| SCHEMBL8367031 | 0.82 | BACE1 (0.47) | BACE1DAOMRGPRX4PPARGPPARA | |
| SCHEMBL8342798 | 0.82 | PPARG (0.50) | BACE1DAOPPARGPPARALMNA | |
| SCHEMBL8099663 | 0.82 | MTNR1A (0.49) | LTA4HMTNR1AMTNR1B | |
| SCHEMBL8515213 | 0.79 | SLC6A4 (0.47) | BACE1DAOMRGPRX4 | |
| SCHEMBL3455724 | 0.78 | ACACB (0.48) | BACE1DAOMRGPRX4PPARGPPARA | |
| SCHEMBL8092697 | 0.78 | MTNR1A (0.54) | LTA4HLMNAMTNR1AMTNR1B | |
| SCHEMBL28247826 | 0.78 | PPARG (0.59) | MRGPRX4PPARGPPARALTA4HLMNA | |
| SCHEMBL30370135 | 0.78 | MAOB (0.44) | DAOMRGPRX4PPARGPPARANLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038271-A9 | AMINO-5- [4- (DIFLUOROMETHOXY) PHENYL] -5-PHENYLIMIDAZOLONE COMPOUNDS AS INHIBITORS OF THE BETA-SECRETASE (BACE) | WYETH CORP (US) | 2008-05-08 | — | — | WO | disclosed |