Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477885 | 0.87 | L3MBTL1 (0.52) | HTR6BRD4CHRM2CHRM4ADRB1 | |
| SCHEMBL13973050 | 0.87 | HTR6 (0.46) | HTR6BRD4CHRM2CHRM4ADRB1 | |
| SCHEMBL4486014 | 0.74 | POLB (0.57) | HTR6CHRM2CHRM4ADRB1CHRM1 | |
| SCHEMBL4493695 | 0.74 | HDAC1 (0.54) | HTR6CHRM2CHRM4ADRB1CHRM1 | |
| SCHEMBL13960736 | 0.73 | L3MBTL1 (0.48) | BRD4SLC5A1SLC5A2L3MBTL1TSHR | |
| SCHEMBL4674316 | 0.72 | HTR6 (0.64) | HTR6BRD4PIK3CGL3MBTL1TSHR | |
| SCHEMBL13973049 | 0.71 | SMN1; SMN2 (0.43) | SLC5A1SLC5A2L3MBTL1HTT | |
| SCHEMBL4678275 | 0.71 | HTR6 (0.50) | HTR6PIK3CGL3MBTL1DRD4 | |
| SCHEMBL8556616 | 0.71 | TSHR (0.65) | BRD4L3MBTL1TSHRDRD4 | |
| SCHEMBL4475776 | 0.71 | L3MBTL1 (0.46) | L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603880-B1 | QUINOLINONE/BENZOXAZINONE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2008-05-07 | — | — | EP | disclosed |