Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.66 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.66 |
| ▸ | DRD1 | P21728 | 1/20 | 0.66 |
| ▸ | DRD4 | P21917 | 1/20 | 0.66 |
| ▸ | ACHE | P22303 | 1/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.66 |
| ▸ | HTR2A | P28223 | 1/20 | 0.66 |
| ▸ | HTR2C | P28335 | 1/20 | 0.66 |
| ▸ | CCKBR | P32239 | 1/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.66 |
| ▸ | HRH1 | P35367 | 1/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.66 |
| ▸ | DRD3 | P35462 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL142049 | 0.96 | ABCB11 (0.66) | DRD2SLC6A4ABCB11CHRM2HTR1A | |
| Methane SCHEMBL7348385 | 0.96 | HTR1A (0.65) | DRD2SLC6A4ABCB11CHRM2HTR1A | |
| SCHEMBL5993554 | 0.93 | HTR1A (0.62) | DRD2SLC6A4ABCB11CHRM2HTR1A | |
| Methyl Alcohol SCHEMBL718326 | 0.90 | DRD2 (0.69) | DRD2SLC6A4ABCB11CHRM2HTR1A | |
| SCHEMBL9101152 | 0.89 | HTR1A (0.68) | DRD2SLC6A4ABCB11CHRM2HTR1A | |
| Methyl Alcohol SCHEMBL929693 | 0.88 | CHRM2 (0.65) | DRD2SLC6A4ABCB11CHRM2HTR1A | |
| Methyl Alcohol SCHEMBL929694 | 0.88 | ABCB11 (0.66) | DRD2SLC6A4ABCB11CHRM2HTR1A | |
| Methyl Alcohol SCHEMBL718327 | 0.87 | HTR1A (0.76) | DRD2SLC6A4ABCB11CHRM2HTR1A | |
| SCHEMBL5995122 | 0.87 | HTR1A (0.67) | DRD2HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL1545933 | 0.86 | HTR1A (0.66) | DRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458507-B1 | Antipsychotic treatment based on SNP genotype | VANDA PHARMACEUTICALS, INC. (US) | 2016-10-04 | — | — | US | claimed |
| US-20160265060-A1 | ANTIPSYCHOTIC TREATMENT BASED ON SNP GENOTYPE | VANDA PHARMACEUTICALS, INC. | 2016-09-15 | — | — | US | claimed |
| US-9328387-B2 | Antipsychotic treatment based on SNP genotype | VANDA PHARMACEUTICALS, INC. (US) | 2016-05-03 | — | — | US | claimed |
| US-20100292211-A1 | ANTIPSYCHOTIC TREATMENT BASED ON SNP GENOTYPE | VANDA PHARMACEUTICALS, INC. | 2010-11-18 | — | — | US | claimed |
| US-20100249188-A1 | PREDICTION OF QT PROLONGATION BASED ON SNP GENOTYPE | VANDA PHARMACEUTICALS, INC. | 2010-09-30 | — | — | US | claimed |
| EP-2198048-A2 | PREDICTION OF QT PROLONGATION BASED ON SNP GENOTYPE | Vanda Pharmaceuticals Inc. (US) | 2010-06-23 | — | — | EP | claimed |
| EP-2198049-A1 | ANTIPSYCHOTIC TREATMENT BASED ON SNP GENOTYPE | Vanda Pharmaceuticals Inc. (US) | 2010-06-23 | — | — | EP | claimed |
| WO-2009036100-A2 | PREDICTION OF QT PROLONGATION BASED ON SNP GENOTYPE | VANDA PHARMACEUTICALS, INC. (US) | 2009-03-19 | — | — | WO | claimed |
| WO-2009036056-A1 | ANTIPSYCHOTIC TREATMENT BASED ON SNP GENOTYPE | VANDA PHARMACEUTICALS, INC. (US) | 2009-03-19 | — | — | WO | claimed |
| US-RE39198-E1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgesics | AVENTIS PHARMACEUTICALS INC. (US) | 2006-07-18 | — | — | US | claimed |
| US-5364866-A | Side effect reduction | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1994-11-15 | — | — | US | claimed |
| EP-0612318-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-08-31 | — | — | EP | claimed |
| EP-0542136-A1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-19 | — | — | EP | claimed |
| WO-1993009102-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1993-05-13 | — | — | WO | claimed |
| US-20230190727-A1 | METHOD OF TREATMENT OF SCHIZOPHRENIA | VANDA PHARMACEUTICALS INC. | 2023-06-22 | — | — | US | disclosed |
| US-11607408-B2 | Method of treatment of schizophrenia | VANDA PHARMACEUTICALS INC. (US) | 2023-03-21 | — | — | US | disclosed |
| US-11214827-B2 | Genetic markers for enhancing efficacy of antipsychotic treatment with iloperidone | VANDA PHARMACEUTICALS INC. (US) | 2022-01-04 | — | — | US | disclosed |
| EP-0612318-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-08-31 | — | — | EP | disclosed |
| EP-0542136-A1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-19 | — | — | EP | disclosed |
| WO-1993009102-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1993-05-13 | — | — | WO | disclosed |