Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237833 | 0.84 | NPC1 (0.41) | FAAHMAOBNPC1PPARGPPARA | |
| SCHEMBL25436650 | 0.80 | PPARG (0.40) | MAOBNPC1PPARGPPARAALDH1A1 | |
| SCHEMBL29168241 | 0.80 | PPARG (0.43) | FAAHMAOBNPC1PPARGPPARA | |
| SCHEMBL29168242 | 0.80 | PPARG (0.43) | FAAHMAOBNPC1PPARGPPARA | |
| SCHEMBL14208211 | 0.79 | EPHX2 (0.50) | FAAHMAOBPPARGPPARAALDH1A1 | |
| SCHEMBL17171336 | 0.78 | HPGD (0.64) | FAAHNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL7372064 | 0.78 | HPGD (0.64) | FAAHNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL14208222 | 0.76 | PPARG (0.53) | MAOBNPC1PPARGPPARAALDH1A1 | |
| SCHEMBL21400206 | 0.76 | NPC1 (0.46) | MAOBNPC1PPARGPPARAALDH1A1 | |
| SCHEMBL1454266 | 0.76 | PPARG (0.53) | MAOBNPC1PPARGPPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194757-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-07-12 | — | — | US | disclosed |
| US-20180105503-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-04-19 | — | — | US | disclosed |
| US-9828367-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-11-28 | — | — | US | disclosed |
| US-9771337-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-09-26 | — | — | US | disclosed |
| US-20170088526-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-03-30 | — | — | US | disclosed |
| US-20170008880-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-01-12 | — | — | US | disclosed |
| US-9499487-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-11-22 | — | — | US | disclosed |
| US-9422245-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150158819-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-06-11 | — | — | US | disclosed |
| US-8993752-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140073783-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2014-03-13 | — | — | US | disclosed |
| US-8513244-B2 | Neprilysin inhibitors | THERAVANCE, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20120309724-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-12-06 | — | — | US | disclosed |
| US-20120308587-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-12-06 | — | — | US | disclosed |
| US-20120308588-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309724-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | FAAH 876/4885MAOB 259/4885NPC1 226/4885 |
| US-20180194757-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | FAAH 552/4885MAOB 253/4885NPC1 186/4885 |
| US-20120308588-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | FAAH 734/4885MAOB 223/4885NPC1 214/4885 |
| US-20140073783-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | FAAH 552/4885MAOB 253/4885NPC1 186/4885 |
| US-20120308587-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | FAAH 552/4885MAOB 253/4885NPC1 186/4885 |
| US-20180105503-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | FAAH 876/4885MAOB 259/4885NPC1 226/4885 |
| US-20170088526-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | FAAH 876/4885MAOB 259/4885NPC1 226/4885 |
| US-20150158819-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | FAAH 552/4885MAOB 253/4885NPC1 186/4885 |
| US-20170008880-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | FAAH 552/4885MAOB 253/4885NPC1 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.