Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14208208 | 0.84 | FAAH (0.43) | NPC1PPARGPPARAALDH1A1FAAH | |
| SCHEMBL29168241 | 0.81 | PPARG (0.43) | NPC1PPARGPPARAALDH1A1FAAH | |
| SCHEMBL29168242 | 0.81 | PPARG (0.43) | NPC1PPARGPPARAALDH1A1FAAH | |
| SCHEMBL7801239 | 0.81 | NLN (0.50) | — | |
| SCHEMBL22800761 | 0.80 | FAAH (0.37) | FAAHSLC1A5MEN1KMT2A | |
| SCHEMBL7269254 | 0.79 | SLC7A5 (0.56) | FAAHHDAC8 | |
| SCHEMBL7438290 | 0.79 | SLC7A5 (0.56) | FAAHHDAC8 | |
| SCHEMBL2153012 | 0.79 | ALDH1A1 (0.50) | NPC1PPARGPPARAALDH1A1SLC6A2 | |
| SCHEMBL1066220 | 0.79 | ALDH1A1 (0.50) | NPC1PPARGPPARAALDH1A1SLC6A2 | |
| SCHEMBL4595262 | 0.79 | ALDH1A1 (0.50) | NPC1PPARGPPARAALDH1A1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012166390-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-12-06 | — | — | WO | disclosed |