Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 5/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420481 | 0.77 | SMN1; SMN2 (0.55) | HTTSMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL1420923 | 0.76 | HTT (0.54) | HTTSMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL1420103 | 0.75 | SMN1; SMN2 (0.51) | HTTSMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL10990213 | 0.67 | KDM4E (0.58) | SMN1; SMN2ALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL23656503 | 0.67 | LMNA (0.55) | HTTSMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL9749227 | 0.66 | CA2 (0.41) | — | |
| SCHEMBL17693398 | 0.65 | MAPK1 (0.44) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL22876029 | 0.65 | KDM4E (0.45) | HTTSMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL23656515 | 0.64 | SCN9A (0.51) | SMN1; SMN2LMNAKDM4EL3MBTL1MAPT | |
| SCHEMBL8807094 | 0.64 | HTT (0.61) | HTTSMN1; SMN2ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297139-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009153307-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |