Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PRNP | P04156 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1244982 | 0.82 | PLA2G4A (0.41) | GABRA5GABRB2HSD17B10PLA2G4AKMT2A | |
| SCHEMBL128514 | 0.82 | GABRA5 (0.39) | GABRA5GABRB2HSD17B10PLA2G4AKMT2A | |
| SCHEMBL4911470 | 0.82 | KMT2A (0.39) | GABRA5GABRB2HSD17B10KMT2AMEN1 | |
| SCHEMBL4890454 | 0.82 | SMN1; SMN2 (0.50) | GABRA5GABRB2HSD17B10PLA2G4AKMT2A | |
| SCHEMBL1614004 | 0.82 | ALDH1A1 (0.39) | GABRA5GABRB2HSD17B10PLA2G4AKMT2A | |
| SCHEMBL17006970 | 0.82 | GABRA5 (0.39) | GABRA5GABRB2HSD17B10PLA2G4AKMT2A | |
| SCHEMBL22685319 | 0.80 | HDAC1 (0.36) | GABRA5GABRB2HSD17B10PLA2G4AKMT2A | |
| SCHEMBL19718381 | 0.79 | KDM4E (0.39) | GABRA5GABRB2HSD17B10KMT2AMEN1 | |
| SCHEMBL2877357 | 0.79 | PLA2G4A (0.43) | GABRA5GABRB2HSD17B10PLA2G4AKMT2A | |
| Formaldehyde SCHEMBL28793964 | 0.79 | SMN1; SMN2 (0.47) | GABRA5GABRB2HSD17B10PLA2G4AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108064224-A | Amide-substituted thiazoles as modulators of Ror gamma t | 詹森药业有限公司 | 2018-05-22 | — | — | CN | disclosed |
| EP-3212643-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt | Janssen Pharmaceutica, N.V. (BE) | 2017-09-06 | — | — | EP | disclosed |
| EP-2778156-B1 | Phenoxypyridinylamide derivatives and their use in the treatment of PDE4 mediated disease states | ASTRAZENECA AB (SE) | 2016-11-30 | — | — | EP | disclosed |
| WO-2016069974-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2016-05-06 | — | — | WO | disclosed |
| EP-2778156-A1 | Phenoxypyridinylamide derivatives and their use in the treatment of PDE4 mediated disease states | AstraZeneca AB (Publ) (SE) | 2014-09-17 | — | — | EP | disclosed |
| CN-102105448-B | Phenoxypyridinylamide derivatives and use thereof in the treatment of PDE4 mediated disease states | ASTRAZENECA AB | 2013-11-13 | — | — | CN | disclosed |
| US-8273774-B2 | Phenoxypyridinylamide compounds | ASTRAZENECA AB (SE) | 2012-09-25 | — | — | US | disclosed |
| CN-102105448-A | Phenoxypyridinylamide derivatives and their use in the treatment of PDE4 mediated disease states | ASTRAZENECA AB | 2011-06-22 | — | — | CN | disclosed |
| EP-2297106-A1 | PHENOXYPYRIDINYLAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PDE4 MEDIATED DISEASE STATES | AstraZeneca AB (SE) | 2011-03-23 | — | — | EP | disclosed |
| US-20100041638-A1 | Chemical Compounds 293 | ASTRAZENECA AB (SE) | 2010-02-18 | — | — | US | disclosed |
| WO-2009144494-A1 | PHENOXYPYRIDINYLAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PDE4 MEDIATED DISEASE STATES | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041638-A1 | Chemical Compounds 293 | PDE4B, PDE4A, PDE3B | GABRA5 2666/4885GABRB2 2388/4885HSD17B10 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.