Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | APEX1 | P27695 | 2/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12735917 | 0.84 | HRH4 (0.47) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| SCHEMBL9751643 | 0.83 | HRH3 (0.50) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| SCHEMBL29312929 | 0.83 | HRH4 (0.46) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| SCHEMBL17119227 | 0.83 | HRH3 (0.50) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| SCHEMBL11117873 | 0.81 | HRH3 (0.47) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| SCHEMBL16557054 | 0.78 | HRH4 (0.41) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| SCHEMBL13550919 | 0.78 | HRH4 (0.45) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| SCHEMBL19723979 | 0.78 | HRH3 (0.49) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| SCHEMBL14031450 | 0.78 | HRH3 (0.42) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| L-Histidinal SCHEMBL12652228 | 0.77 | HRH4 (0.59) | HRH4HRH3ALDH1A1NFKB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329725-B2 | Annelated pyrrolidin sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals | SANOFI (FR) | 2012-12-11 | — | — | US | disclosed |