Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480192 | 0.77 | IGF1R (0.65) | IGF1REPHB4AURKBKDRPTK2 | |
| SCHEMBL4946510 | 0.74 | EPHB4 (0.69) | IGF1REPHB4AURKBKDRPTK2 | |
| SCHEMBL1927928 | 0.74 | IGF1R (0.61) | IGF1REPHB4AURKBKDRPTK2 | |
| SCHEMBL13955883 | 0.74 | IGF1R (0.59) | IGF1REPHB4AURKBKDRPTK2 | |
| SCHEMBL14214721 | 0.74 | IGF1R (0.68) | IGF1REPHB4AURKBKDRPTK2 | |
| SCHEMBL14214584 | 0.72 | IGF1R (0.66) | IGF1REPHB4AURKBKDRPTK2 | |
| SCHEMBL21067672 | 0.72 | EPHB4 (1.00) | IGF1REPHB4AURKBKDRPTK2 | |
| SCHEMBL17394819 | 0.72 | POLB (0.56) | IGF1REPHB4AURKBKDRPTK2 | |
| SCHEMBL14088802 | 0.72 | IGF1R (0.62) | IGF1REPHB4AURKBKDRTEK | |
| SCHEMBL14214734 | 0.71 | IGF1R (0.57) | IGF1REPHB4AURKBKDRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |