Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | ILK | Q13418 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3330523 | 0.85 | ALDH1A1 (0.44) | BRD4ALDH1A1NPC1MAPTHSD17B10 | |
| SCHEMBL2024194 | 0.84 | BRD4 (0.41) | BRD4ALDH1A1NPC1MAPTHSD17B10 | |
| SCHEMBL11708039 | 0.84 | BRD4 (0.41) | BRD4ALDH1A1NPC1MAPTHSD17B10 | |
| SCHEMBL27757230 | 0.81 | BRD4 (0.40) | BRD4ALDH1A1NPC1MAPTHSD17B10 | |
| SCHEMBL29598453 | 0.80 | KDM4E (0.42) | BRD4ALDH1A1NPC1MAPTHSD17B10 | |
| SCHEMBL29598150 | 0.80 | HDAC3 (0.39) | BRD4ALDH1A1NPC1MAPTHSD17B10 | |
| SCHEMBL29605580 | 0.80 | CYP4F2 (0.42) | BRD4ALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL29572339 | 0.80 | CYP4F2 (0.43) | BRD4ALDH1A1HSD17B10TSHRKDM4E | |
| SCHEMBL2022385 | 0.80 | TSHR (0.44) | BRD4ALDH1A1NPC1MAPTHSD17B10 | |
| SCHEMBL29597836 | 0.79 | BRD4 (0.41) | BRD4ALDH1A1NPC1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080124384-A1 | Heteroaryl Substituted Piperazinyl-Pyridine Analogues | NEUROGEN CORPORATION | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080124384-A1 | Heteroaryl Substituted Piperazinyl-Pyridine Analogues | PIGO, GPR52, GPR88 | BRD4 716/4885ALDH1A1 1028/4885NPC1 2700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.