Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.76 |
| ▸ | KDR | P35968 | 3/20 | 0.76 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.76 |
| ▸ | PTK2 | Q05397 | 10/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.51 |
| ▸ | MTOR | P42345 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214727 | 0.85 | KDR (0.71) | LCKKDRMAPK14PTK2IGF1R | |
| SCHEMBL14214730 | 0.85 | KDR (0.82) | LCKKDRMAPK14PTK2IGF1R | |
| SCHEMBL6478410 | 0.84 | KDR (0.80) | LCKKDRMAPK14PTK2IGF1R | |
| SCHEMBL6480335 | 0.84 | LCK (0.71) | LCKKDRMAPK14PTK2IGF1R | |
| SCHEMBL6478730 | 0.84 | KDR (0.77) | LCKKDRMAPK14PTK2IGF1R | |
| SCHEMBL6480028 | 0.84 | KDR (0.77) | LCKKDRMAPK14PTK2IGF1R | |
| SCHEMBL14214609 | 0.84 | KDR (0.87) | LCKKDRMAPK14PTK2IGF1R | |
| SCHEMBL14214615 | 0.83 | KDR (0.85) | LCKKDRMAPK14PTK2IGF1R | |
| SCHEMBL14214616 | 0.82 | KDR (0.84) | LCKKDRMAPK14PTK2IGF1R | |
| SCHEMBL14214614 | 0.82 | KDR (0.78) | LCKKDRMAPK14PTK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |