Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28037898 | 0.84 | KCNH2 (0.54) | KDM4ESMN1; SMN2RAB9AKCNH2SCN9A | |
| SCHEMBL28051328 | 0.84 | TRPV1 (0.58) | KDM4ESMN1; SMN2RAB9AMAPK8CDC7 | |
| SCHEMBL29824523 | 0.82 | MAPT (0.68) | KDM4EMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL15875869 | 0.82 | MAPT (0.68) | KDM4EMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL13064959 | 0.80 | KDM4E (0.69) | KDM4EMAPTGAASMN1; SMN2RAB9A | |
| SCHEMBL16748602 | 0.77 | BMI1 (0.47) | KDM4EMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL28051498 | 0.77 | IDH2 (0.53) | KDM4ESMN1; SMN2RAB9AKCNH2SCN9A | |
| SCHEMBL28051330 | 0.77 | ADORA3 (0.59) | KDM4ESMN1; SMN2KCNH2SCN9ACDK2 | |
| SCHEMBL16747849 | 0.76 | SCN5A (0.57) | KDM4EMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL28104565 | 0.75 | MAPT (0.54) | KDM4EMAPTALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |