Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.51 |
| ▸ | IGF1R | P08069 | 3/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214743 | 0.85 | TEK (0.65) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214737 | 0.82 | TEK (0.68) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6480089 | 0.80 | TEK (0.69) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214551 | 0.78 | TEK (0.78) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6480986 | 0.78 | TEK (0.74) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214552 | 0.78 | TEK (0.81) | TEKKDRFGFR3FGFR2FGFR1 | |
| SCHEMBL14214554 | 0.78 | TEK (0.74) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214739 | 0.77 | TEK (0.82) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6479711 | 0.77 | TEK (0.73) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214736 | 0.76 | TEK (0.75) | TEKKDRFGFR3FGFR2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |