Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.49 |
| ▸ | IGF1R | P08069 | 3/20 | 0.46 |
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.44 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214742 | 0.85 | TEK (0.68) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6480089 | 0.78 | TEK (0.69) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214551 | 0.76 | TEK (0.78) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214552 | 0.76 | TEK (0.81) | TEKKDRFGFR3FGFR2 | |
| SCHEMBL6480986 | 0.76 | TEK (0.74) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214554 | 0.76 | TEK (0.74) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214739 | 0.75 | TEK (0.82) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6479711 | 0.75 | TEK (0.73) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL14214736 | 0.74 | TEK (0.75) | TEKKDRFGFR3FGFR2IGF1R | |
| SCHEMBL6481339 | 0.74 | TEK (0.72) | TEKKDRFGFR3FGFR2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |