Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.63 |
| ▸ | GSK3B | P49841 | 6/20 | 0.61 |
| ▸ | CDK2 | P24941 | 3/20 | 0.61 |
| ▸ | SYK | P43405 | 3/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.61 |
| ▸ | IKBKB | O14920 | 2/20 | 0.61 |
| ▸ | FLT1 | P17948 | 2/20 | 0.61 |
| ▸ | FLT4 | P35916 | 2/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | CDC7 | O00311 | 1/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | CHUK | O15111 | 1/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12423165 | 0.88 | PIK3CG (0.68) | PIK3CGPIK3CAPIK3CBEGFRGSK3B | |
| SCHEMBL14216065 | 0.85 | SYK (0.69) | PIK3CGPIK3CAPIK3CBEGFRGSK3B | |
| SCHEMBL7473582 | 0.85 | CDK2 (0.65) | PIK3CGPIK3CAPIK3CBGSK3BCDK2 | |
| SCHEMBL7468142 | 0.84 | PIK3CG (0.67) | PIK3CGPIK3CAPIK3CBEGFRGSK3B | |
| SCHEMBL28776128 | 0.84 | PIK3CG (0.66) | PIK3CGPIK3CAPIK3CBEGFRGSK3B | |
| SCHEMBL6156552 | 0.82 | CDK2 (0.72) | PIK3CGPIK3CAPIK3CBEGFRGSK3B | |
| SCHEMBL14562071 | 0.82 | PIK3CG (0.64) | PIK3CGPIK3CAPIK3CBEGFRGSK3B | |
| SCHEMBL27116598 | 0.82 | PIK3CG (0.83) | PIK3CGPIK3CAPIK3CBEGFRGSK3B | |
| SCHEMBL2284467 | 0.82 | PIK3CG (0.64) | PIK3CGPIK3CAPIK3CBEGFRGSK3B | |
| SCHEMBL13154300 | 0.81 | GSK3B (0.57) | PIK3CGPIK3CAPIK3CBEGFRGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |