Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.52 |
| ▸ | FLT3 | P36888 | 3/20 | 0.52 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.52 |
| ▸ | CDK8 | P49336 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1423904 | 0.90 | MEN1 (0.52) | ABCB1ABCG2CYP1B1FLT3MEN1 | |
| SCHEMBL1976256 | 0.88 | MAPT (0.67) | MAOBCYP19A1MAPTABCB1NPC1 | |
| SCHEMBL24514602 | 0.81 | CYP1A1 (0.75) | MAPTABCB1ABCG2CYP1B1FLT3 | |
| SCHEMBL1421600 | 0.81 | ABCG2 (0.67) | MAPTABCB1NPC1CYP3A4CYP2C9 | |
| SCHEMBL24514601 | 0.81 | ABCB1 (0.73) | ABCB1ABCG2CYP1B1MEN1ALDH1A1 | |
| SCHEMBL1421607 | 0.80 | FLT3 (0.56) | MAOBCYP19A1MAPTABCB1NPC1 | |
| SCHEMBL24514598 | 0.80 | ABCB1 (0.68) | ABCB1ABCG2CYP1B1MEN1ALDH1A1 | |
| SCHEMBL7156543 | 0.79 | ABCB1 (0.69) | ABCB1ABCG2CYP1B1MEN1ALDH1A1 | |
| SCHEMBL7306849 | 0.78 | MAPT (0.74) | MAOBCYP19A1MAPTABCB1NPC1 | |
| SCHEMBL8062100 | 0.78 | MEN1 (0.71) | MAPTABCB1ABCG2FLT3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297127-A1 | CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | AxoGlia Therapeutics S.A. (LU) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009130253-A1 | CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | AXOGLIA THERAPEUTICS S.A. (LU) | 2009-10-29 | — | — | WO | disclosed |