Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.70 |
| ▸ | AURKA | O14965 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 7/20 | 0.67 |
| ▸ | EGFR | P00533 | 6/20 | 0.67 |
| ▸ | FLT4 | P35916 | 2/20 | 0.64 |
| ▸ | CIT | O14578 | 1/20 | 0.64 |
| ▸ | GAK | O14976 | 1/20 | 0.64 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.64 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.64 |
| ▸ | STK17B | O94768 | 1/20 | 0.64 |
| ▸ | STK10 | O94804 | 1/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28350751 | 0.86 | SRC (0.77) | SRCAURKAKDREGFRKDM4E | |
| SCHEMBL28354322 | 0.85 | SRC (0.73) | SRCAURKAKDREGFRFLT4 | |
| SCHEMBL28350783 | 0.85 | SRC (0.73) | SRCAURKAKDREGFRFLT4 | |
| SCHEMBL13529060 | 0.83 | SRC (0.84) | SRCAURKAKDREGFRFLT4 | |
| SCHEMBL28354676 | 0.83 | SRC (0.77) | SRCAURKAKDREGFRFLT4 | |
| SCHEMBL28882352 | 0.83 | SRC (0.77) | SRCAURKAKDREGFRFLT4 | |
| Hydrochloric Acid SCHEMBL4379495 | 0.83 | SRC (0.74) | SRCAURKAKDREGFRFLT4 | |
| SCHEMBL3531151 | 0.83 | SRC (0.86) | SRCAURKAKDREGFRFLT4 | |
| SCHEMBL14421402 | 0.82 | AURKA (0.64) | SRCAURKAKDREGFRLCK | |
| SCHEMBL5025344 | 0.82 | AURKA (0.64) | SRCAURKAKDREGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299381-B1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2002000649-A9 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |