Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.59 |
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | PDE4A | P27815 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319936 | 0.91 | KMT2A (0.60) | NPC1RAB9APDE4APDE4BPDE4C | |
| SCHEMBL8269325 | 0.89 | RAB9A (0.56) | NPC1RAB9APDE4APDE4BPDE4C | |
| SCHEMBL14376022 | 0.86 | POLB (0.58) | NPC1RAB9APOLBSMN1; SMN2MAPT | |
| SCHEMBL8271318 | 0.86 | PDE4A (0.55) | NPC1RAB9APDE4APDE4BPDE4C | |
| SCHEMBL4817190 | 0.85 | PDE4A (0.72) | NPC1RAB9APDE4APDE4BPDE4C | |
| SCHEMBL8313283 | 0.85 | PDE4A (0.72) | NPC1RAB9APDE4APDE4BPDE4C | |
| SCHEMBL4817196 | 0.85 | PDE4A (0.72) | NPC1RAB9APDE4APDE4BPDE4C | |
| SCHEMBL4820685 | 0.84 | NPC1 (0.67) | NPC1RAB9APOLBSMN1; SMN2MAPT | |
| SCHEMBL14375503 | 0.82 | PDE4A (0.57) | NPC1RAB9APDE4APDE4BPDE4C | |
| SCHEMBL8322445 | 0.82 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080114061-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114061-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | NPC1 789/4885RAB9A 4576/4885PDE4A 2547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.